Improving dissolution profile of poorly water-soluble drug using non-ordered mesoporous silica

Influence of Solid Drug Delivery System Formulation on Poorly Water-Soluble Drug Dissolution and Permeability.

The majority of drugs have a low dissolution rate, which is a limiting step for their absorption. In this manuscript, solid dispersions (SD), solid self-microemulsifying drug delivery systems (S-SMEDDS) and solid self-nanoemulsifying drug delivery systems (S-SNEDDS) were evaluated as potential formulation strategies to increase the dissolution rate of carbamazepine. Influence of increased disso...

soluplus®; a novel excipient to improve dissolution rate of poorly water soluble drug, celecoxib

Dissolution of Mesoporous Silica Supports in Aqueous Solutions: Implications for Mesoporous Silica-based Water Treatment Processes.

Under pH 7 - 10 conditions, the mesoporous silica supports proposed for use in water treatment are relatively unstable. In batch experiments conducted in pH 7 solutions, the commonly used support SBA-15 dissolved quickly, releasing approximately 30 mg/L of dissolved silica after 2 hours. In column experiments, more than 45% of an initial mass of 0.25 g SBA-15 dissolved within 2 days when a pH 8...

Mesoporous silica- and silicon-based materials as carriers for poorly water soluble drugs

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Dissolution Behavior and Thermodynamic Stability of Fused-Sugar Dispersions of a Poorly Water-Soluble Drug

The current research was undertaken to develop and evaluate dissolution profiles of thermodynamically stabilized sugar dispersions of the poorly water-soluble, model drug etoricoxib (ETX). Fused-sugar dispersions were formulated using sorbitol, xylitol, and maltose separately, and the binary systems were stabilized by incorporation of the antiplasticizing agents poloxamer 407 and PVP K30 to obt...